Item – Theses Canada

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OCLC number
1032923285
Link(s) to full text
LAC copy
LAC copy
Author
Vincent, Akshita K.
Title
Epigenetic Alterations Associated with Uropathogenic Escherichia coli (UPEC) Infections in the Bladder.
Degree
MAST -- University of Toronto, 2014
Publisher
Toronto : University of Toronto, 2014.
Description
1 online resource
Notes
Includes bibliographical references.
Abstract
Infection of the human urinary tract is one of the commonest bacterial infections, with uropathogenic E.coli (UPEC) being responsible for 90% of the diagnosed cases, with significant morbidity and mortality. The urinary bladder is a remarkable autonomic musculomembranous organ under conscious control. Its two main functions are, storage and voiding of urine. Any disturbance to normal urination leads to various clinical conditions, such as urinary incontinence, bladder retention, overactive bladder syndrome, prostatitis in men and urinary tract infections (UTI). Determining the predisposition of an individual to UTI by discovering a biomarker would allow for a more rational selection of patients who might best benefit from either antibiotic prophylaxis or preemptive surgical intervention. The purpose of this study was to examine the epigenetic effects of UPEC infection directly, or indirectly in the bladder. The study also identified potential gene candidates, such as TLR4 and CTCF, for development of DNA methylation biomarker targets.
Other link(s)
hdl.handle.net
tspace.library.utoronto.ca
Subject
Bladder.
Epigenetics.
Uropathogenic Escherichia coli.
Health Care Management 0769.